Bus from Mexico City to Guadalajara
Travel from Mexico City to Guadalajara with Primera Plus. Choose from up to 19 daily departures, with a scheduled journey of approximately 6h 30min. Book online in advance to access special offers and lower prices.
Mexico City → Guadalajara at a glance
Current route information based on the checked Primera Plus schedule.
Save money online
Book online in advance for special offers and lower prices.
6h 30min
Scheduled journey
451.5 km
Straight-line distance
19/day
Departures on the checked date
Benefits of Traveling With Primera Plus
Luggage Included
Your ticket includes 25kg of checked-in luggage plus a carry-on bag.
Entertainment & WiFi
Onboard TV and WiFi available to stay connected with your loved ones.
Online Ticket
Buy your ticket online and skip the lines on the terminal.
Travel Protected
Add Primera Plus Additional Coverage online and enjoy every mile with greater peace of mind. Get support for unexpected cancellations, travel interruptions, checked baggage issues, and more.
Flexible Ticket
Change your travel date or departure time once, up to one hour before your scheduled journey.
Travel Risk-Free
You can cancel your tickets purchased online. Refunds are returned directly to the card used for payment within 15 business days, plus your bank’s processing time.
How To Reach Out
Modify your ticket through our WhatsApp channel or call +52 477 710 0060 from 05:30 to 23:50.
Luxury Seats
Your comfort is our priority. We offer reclinable chairs with maximum leg space for your comfort.
Pet-friendly
Bring your companion along. Pets can travel safely in the designated luggage area when documented before boarding. Assistance dogs are welcome.
Toilets On Board
Sanitized and clean toilets to travel faster without stops to your destination.
USB Chargers
Charge your devices while traveling through our USB charging ports available on board.
Take Your Bike
Bring your bike on board, subject to availability and staff approval at counter. You may be asked to remove the front wheel, and extra charges can apply if it exceeds your 25 kg baggage allowance or the 1.10 m size limit; transport is at your own risk.
Departure and arrival stations
Check the terminal names and locations before starting your journey.
Mexico City Northern Bus Station
Eje Central Lázaro Cardenas, 07760, Mexico City
Guadalajara Bus Station Modulo 2-3
Central Nueva Camionera Módulo 2-3, Guadalajara JA
What to see in Guadalajara
Three well-known places to explore after arriving in the city.
Explore the central plazas, cathedral and historic streets in the heart of the city.
Historic Centre of Guadalajara
Visit the landmark cultural complex known for its architecture, courtyards and murals.
Hospicio Cabañas
Discover galleries, crafts, restaurants and pedestrian streets in this traditional district.
Tlaquepaque
Other Primera Plus routes
Explore the return journey and other popular connections in the network.
Guadalajara → Mexico City
6h 30min scheduled journey with up to 19 departures on the checked service date.
Guadalajara → Puerto Vallarta
4h 30min scheduled journey with up to 15 departures on the checked service date.
Puerto Vallarta → Guadalajara
4h 30min scheduled journey with up to 14 departures on the checked service date.
Mexico City → Morelia
4h 20min scheduled journey with up to 12 departures on the checked service date.
Frequently asked questions
Useful information for the Mexico City to Guadalajara bus route.
Travel from Mexico City to Guadalajara
Primera Plus connects Mexico City Northern Bus Station with Guadalajara Bus Station Modulo 2-3. The checked schedule shows up to 19 departures and a scheduled journey of approximately 6h 30min.
Book online before travelling to compare current departure times and availability for your chosen date, and to access online offers. Confirm your terminal details before leaving for the station.